If a structure is pasted to a cell, which is referred by a JCMarkushMatch function, memory usage of JChem for Excel may increase to an inconvenient level in some environments, which can result in rare cases in the crash of the application.
The reason for this is that to perform the Markush search the whole Markush library is enumerated in the background, which needs extra memory usage.
What the user experiences:
The user experiences an unusual long time when pasting a structure to an empty cell: after pressing the "Paste" JChem ribbon button or the "Ctrl+V" keyboard button combination, sandglass may appear in Excel and the user needs to wait until the structure is pasted. This happens only if the structure is pasted to a cell, which is referred by a JCMarkushMatch function.
Time need of the copy-paste process is normal if the structure is pasted to an empty cell, which is not referred by a JCMarkushMatch function.
Please wait until the paste process is finished. If crash happens, please don't disable the add-in (see more about this in the following Solution Article: